Christian Siriano purchased a house for his mother, Joye Siriano in Virginia, and he shared how he kept it a secret for a year while attending City Harvest’s Carnival event on April 22 in New York City’s Cipriani

Princess Charlene of Monaco’s legs have never looked longer in bridal white flares during an event hosting the Prince and Grand Master of Malta at the palace on Tuesday.

David and Victoria Beckham’s Miami mansion sits right on the glittering waters of Biscayne Bay, and the terrace on their beautiful home’s decking is a sight to behold. The famous family bought to home last year for a cool $60 million…

Midsomer Murders star John Nettles left his daughter in Jersey when his Bergerac commitments ended – and here’s why

Meghan Markle, the wife of Prince Harry, looked resplendent in a stunning tan outfit at a TIME100 event on Wednesday.

A toxin produced by E. coli – the troublesome bug that causes vomiting and fevers – could be behind rising bowel cancer rates.

The disease, also called colorectal cancer, predominantly impacts people over 50 though for the last two decades has begun to impact more young people worldwide.

Many of these countries are richer nations in the west – including England – with poor diet, obesity and eating too much meat among the risk factors.

But exposure to a toxin produced by the bacteria E. coli could also be a factor, researchers revealed today.

Exposure to colibactin as a child can mess up the genetic signature on the DNA of bowel cells, which may increase the chance of developing bowel cancer when younger than 50, a study published today found.

This changes people’s digestive tracks and raises the risk of tumours forming, the researches said, with traces of colibactin found lurking in tumours from patients under 40.

The research, led by the University of California San Diego (UCSD) and published in the journal Nature, saw experts examine 981 bowel cancer genomes from patients with both early and late-onset disease in 11 different countries.

Colibactin’s specific pattern of DNA mutations were 3.3 more common in early-onset bowel cancer cases (in adults under 40) than in those diagnosed after the age of 70.

‘These mutation patterns are a kind of historical record in the genome, and they point to early-life exposure to colibactin as a driving force behind early-onset disease,’ said senior author, Ludmil Alexandrov, a professor at UCSD.

They also found that colibactin-related mutations account for around 15% of APC driver mutations, one of the first genes to go haywire in bowel cancer.

First author Marcos Diaz-Gay, a former postdoctoral researcher, said: ‘If someone acquires one of these driver mutations by the time they’re 10 years old, they could be decades ahead of schedule for developing colorectal cancer, getting it at age 40 instead of 60.’

The work is part of Cancer Grand Challenges team Mutographs, funded by Cancer Research UK.

The director of Cancer Grand Challenges, Dr David Scott, said the colibactin that seems to be affecting bowel cancer is only produced by some strains of E. Coli.

There are many kinds of E. coli, the bulk harmless to humans and are part of a smooth-running intestinal tract. One strain, known as Shiga toxin-producing E. coli, can be found wriggling in the insentiences of cows and find themselves in faeces, containing farm soil.

The strain that coughs out colibactin is not linked to infection such as diarrhoea in some people, the study said.

‘It’s unclear how the exposure originates, but we suspect that a combination of factors – including diet – may intersect during a crucial phase in the development of the gut microbiome,’ said Dr Scott.

‘This study adds an important piece to the puzzle of early-onset cancers, but it isn’t conclusive, and more research will be needed to establish a definitive link between colibactin and an increased risk of early-onset colorectal cancer.’

Professor Sir Mike Stratton, Mutographs team lead and senior group leader at the Wellcome Sanger Institute, said: ‘Our research has allowed us to generate the hypothesis that the presence of colibactin leads to an increased number of mutations in colon cells, which then causes a greater risk of colorectal cancer at an early age.

‘If this turns out to be correct, we can explore preventive measures such as tests that tell us if the toxin, or the bacterium that makes it, is present, and finding ways to eliminate them from our bodies at a young age.

‘We know that diet and lifestyle choices drive the risk of developing colorectal cancer, but this study has opened up a new and exciting route we can take when researching how to lower the rate of early-onset colorectal cancer.’

Get in touch with our news team by emailing us at webnews@metro.co.uk.

For more stories like this, check our news page.

Princess Eugenie looked incredible during her visit to a cancer unit with her mother Sarah Ferguson, Duchess of York and Princess Beatrice on Wednesday.

Princess Beatrice, cousin of Prince William and Prince Harry, was an absolute vision during her family appearance in a navy dress, when she paid a visit to a teenage cancer unit with her mother Sarah Ferguson and sister Princess Eugenie.

Marks & Spencer has dropped a chic strapless polka dot dress that’s gone viral on Instagram and I think Kate Middleton would love it. Shop the look for £79 at M&S.

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Seeing as the sun could be here for a little longer, we’re spending as much time in our garden, patio or balcony for as long as possible – though when the sun sets, sitting outside isn’t as appealing.

Thankfully shoppers are going wild for a set of solar-powered string lights that really brighten up the place (literally!).

Priced at £15, the Scalloped 10 LED Indoor Outdoor Solar String Lights have customers rushing online and in store in the hope you get their hands on a set. With an impressive score of 4.5 out of 5, they’ve been hailed a ‘pretty string of lights’, ‘stunning’, and one person went as far as calling them the ‘best on the market’.

Scalloped 10 LED Indoor Outdoor Solar String Lights

These really are the finishing touch to any outdoor space – and require just 2 AA batteries to get started.

Buy Now for £15

Illuminate your space with the charming Scalloped 10 LED Solar String Lights. Featuring a delicate white scalloped design, these lights house 10 warm white LEDs that offer both constant and flashing settings. Perfect for outdoor use, they effortlessly transform any garden or patio into a cosy retreat. With a total cable length of 5.7 metres and a lit length of 3.88 metres, these solar-powered lights are both practical and stylish, making them an ideal addition to your outdoor décor, don’t you think?

Someone called ‘Kingston Lad’ a few months back called the solar string lights the ‘best on the market’, and added: ‘Excellent lights, look great on our summer house. Bought two sets.’

Another five-star reviewer also said how they are ‘absolutely stunning’, before mentioning: ‘Bought these as a gift for our friends then decided to buy them for myself. They are really pretty and look stunning. The best solar lights I have seen so pleased with them.’

‘Lovely garden lights’ said Garden Light Fan, who then went on to say: ‘Lovely asset to the garden. More expensive than I would normally pay but a cut above the rest.’

Diana said she would ‘buy these again’ and added to her five-star review: ‘Really lovely lights that arrived very quickly. Even better that they were in the sale.’

Better yet, Charlene said the ‘gorgeous lights’ were ‘great quality’ and went on to say: ‘so pretty and perfect for my small patio area.’

Priced at £15, we don’t think these will be in stock for long, especially with a few more bank holidays pending, and plenty of catching up with friends and family into the night are on the cards.

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